By J. Stewart Cameron (auth.), Vittorio E. Andreucci M.D., Antonio Dal Canton M.D. (eds.)
Read or Download Current Therapy in Nephrology: Proceedings of the 2nd International Meeting on Current Therapy in Nephrology Sorrento, Italy, May 22–25, 1988 PDF
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Additional info for Current Therapy in Nephrology: Proceedings of the 2nd International Meeting on Current Therapy in Nephrology Sorrento, Italy, May 22–25, 1988
Et al. J Exp Med: 158:- 718-730, 1983. 4. , et al. Immunol Lett: ~ 187, 1984. 5. , et al. PNAS (USA): 80: 850, 1983. 6. , et al. Lancet: 2:- 417-422, 1984. 7. , et al. Medicine (BaIt): 66: 46-55, 1986. 8. , et al. J Clin Invest: 70: 731, 1985. 9. , et al. Arthritis Rheum: 28: 999-1007, 1985. 10. , and CollinS, e. J Clin Invest:76: 287-294, 1985. 11. , et al. J Clin Immunol: 6: 194-203, 1986. 12. , et al. elin Immunol Immunopathol:38: 302-308, 1986 13. , et al. elin Exp Immunol: 67: 507-515, 1987.
On. When allopurinol was given 4 hours before ADR failed to prevent the progression of the renal disease: proteinuria in this group was only moderately lower than in the untreated rats on day to and day 15 (Tab. I, group C). A diffe- rent outcome of proteinuria was observed when allopurill0l was given immediately after ADR injection (Tab I, group D). 05 vs groups A and B). Tab. 1. inol treatment. 05 vs a. 025 v s b. itory effect of allopurill0l on ADR nephl'otoxicity. Allop- urinol could effectively prevent proteinuria first of all by acting as a general scavenger of free radicals, which may arise from ADR renal metabolism.
Altbougb these data need furtber evaluation we think tbat tbe iJ1hibltion of proteinuria by allopurinol in tbis experimental model could be relevant to tbe future developements in this area of researcb. REF'EREICES 1. B. Lal). II1vest.. 46:16- 23, 1982. 2. A. ems,vol. s (Eds. ler Biomedical, pp 300-303, 1983. 3. H. Anal. Biocbem. 116: 53-64, 1981. 4. E. J. Clin. Invest. 68: 1053-1064, 1981. , Hardonk H. Kidney Int. 987. CLINICAL EXPERIENCE WITH AN ANTITHROMBOTIC IIGENT (DEFIBROTIDE) IN GLOMERULAR DISEASES.