Therapy

Antiviral Nucleosides: Chiral Synthesis and Chemotherapy by C.K. Chu

By C.K. Chu

• updated evaluation at the chemistry and biology of nucleosides • glossy man made technique • finished insurance of antiviral nucleosidesThis e-book summarizes the hot advances in nucleosides chemistry and chemotherapy over the last 10-15 years. It covers lately came upon nucleoside antiviral brokers, their healing points and biochemistry, and in addition wide reports on their chiral synthesis.

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In addition, LBV may be effective in the treatment of GCV-resistant HCMV. LBV has undergone clinical trials as an anti-HBV agent. viral TK for HSV-1/2 and VZV LBV LBV-DP LBV-MP LBV-TP protein kinase for HCMV Broad spectrum antiviral activity Figure 57. Metabolism of lobucavir. 248 NH2 N HO F HO 142 Figure 58. Carbocyclic 3'-fluoro-oxetanocin A. ^"^^ 44 G. Gumina, Y. Choi and C. K. Chu Enzymatic phosphorylation studies indicate that in the (cyclopropyl)methyl derivatives, both the cis- and trans-(hydroxymcihyl) derivatives are reasonably good substrates for the HSV-1 TK in comparison with ACV and its carba analog.

1997, 8, 1-23. ; Hong, J. ; Cooperwood, J. ; Chu, C. K. Recent advances in L-nucleosides: chemistry and biology. Antiviral Res. 1998, 40, 19-44. (g) Crimmins, M. New development in the enantioselective synthesis of cyclopentyl carbocyclic nucleosides. Tetrahedron 1998, 54, 9229-9272. -F. The latest progress in the synthesis of carbocyclic nucleosides. Nucleosides Nucleotides 2000,19, 651-690. ; Song, G. ; Chu, C. K. L-Nucleosides as chemotherapeutic agents. 2001, 202, 9-15. Cj) Cooperwood, J. ; Boudinot, F.

Acyclic nucleosides as antiviral compounds. Mol. Biotechnol. 1996, 5, 125-137. ; De Clercq, E. HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogs: a review of their 54 G. Gumina, Y. Choi and C. K. Chu pharmacology and clinical potential in the treatment of viral infections. Antiviral Chem. Chemther. 1997, 8, 1-23. ; Hong, J. ; Cooperwood, J. ; Chu, C. K. Recent advances in L-nucleosides: chemistry and biology. Antiviral Res. 1998, 40, 19-44. (g) Crimmins, M. New development in the enantioselective synthesis of cyclopentyl carbocyclic nucleosides.

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