Animals

Anticholinergic Drugs and Brain Functions in Animals and Man by P.B. Bradley

By P.B. Bradley

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44 SIGG,E. , DRAKONTIDES, A. B. A N D DAY,C. (1965) Muscarinic inhibition of dendritic postsynaptic potentials in cat cortex. Int. J. , 4,281-289. 45 STEINER, W. G. AND HIMWICH, H. E. (1962) Central cholinolytic action of chlorpromazine. Science, 136, 873-874. , BICKEL, M. H. AND BRODIE, B. B. (1964)The action of desmethylimipramine in counteracting sedation and cholinergic effects of reserpine-like drugs. J. , 141, 321-330. 26 R. P. WHITE A N D A . S. RUDOLPH 47 TEUCHMANN, J. (1949) The action of diallilbarbituric acid and of scopolamine on the spinal reflexes of the decapitated, the decerebrated and the decorticated cat.

N. Acad. , 96, 251-262. 5 BIJLSMA, U. G. AND BROUWER, J. E. (1928) Die Wirkung des Skopolamins in Kombination mit Cyanid, Kohlenoxyd und Luftverdunnung, Arch. exp. Path. , 138, 190-207. 6 BOGDANSKI, D. , WEISSBACH, H. AND UDENFRIEND, S. (1958) Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan. J. , 122, 182-194. 7 BRADLEY, P. B. (1957) Microelectrode approach to the neurnpharmacology of the reticularformatiorr. Psychotropic Drugs. Eds. S. Garattini, V. Ghetti. Elsevier, Amsterdam, 207-216.

The independent nature of the EEG and the evoked responses seen in this study indicate that different processes or neurons are involved in each phenomenon. The evoked phenomenon is also more specific, being obtained only in certain leads; whereas, an EEG was obtained from all locations of the midbrain. Independent variations between the EEG and evoked responses are also evident in intact a n i m a W . It is possible that the neuroglia contribute significantly to the EEG pattern16, and evoked potentials are specific signals so that, at least under the influence of drugs, they may vary independently.

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