Animals

Animals in Scientific Research: An Effective Substitute for by P. Turner

By P. Turner

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Read or Download Animals in Scientific Research: An Effective Substitute for Man?: Proceedings of a Symposium held in April 1982 under the auspices of the Humane Research Trust PDF

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Additional info for Animals in Scientific Research: An Effective Substitute for Man?: Proceedings of a Symposium held in April 1982 under the auspices of the Humane Research Trust

Example text

Base-substitution changes involve the replacement of specific nucleotide bases by other bases which lead to the production of a messenger RNA molecule which contains an informational sequence which deviates from the normal or wild type. Frameshift changes involve the removal or insertion of bases in the DNA which results in changes in the "reading frame" of the genetic information at the level of protein synthesis. These types of changes are illustrated in figure 1. Such changes in nucleotide sequence may lead to the production of proteins containing an abnormal sequence of amino acids (missense) or to the production of a non-coding triplet which leads to chain termination and the production of a shortened protein (nonsense).

Amsterdam . Brewen, J. , Payne, H. , Jones, K. P. and Preston, R. J. (1975). Studies on chemically induced dominant lethality. 1, The cytogenetic basis of MMS-induced dominant lethality in post-meiotic germ cells. Mutation Res. 33, 239-250. Boutwell, R. K. (1974). The function and mechanism of promoters of carcinogenesis. Toxicol. 2, 419-442. Dean, D. J. and Hodson-Walker, G. (1979). An in vitro chromosome assay using cultured rat liver cells. Mutation Res. 64, 329337. de Serres, F. J. and Ashby, J.

Langley, P. , Smith, D. and Taylor D. C. (1974) Metabolism of chloroform I. The metabolism of 14C-chloroform by different species. Xenobiotica, 4, 151-163. Burk, R. F. and Lane, J. M. (1979) Ethane production and liver necrosis in rats after administration of drugs and other chemicals. , 50,467-468. 25, Department of Health and Social Security, London, page 2. Elder, J. B. Gangoli, P. C. and Gillespie, I. E. (1979) Cimetidine and gastric ulcer. Lancet, 1,1005-1006. Frank, L. and Massaro, D. (1980) Oxygen toxicity.

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