Animals and Alternatives in Toxicology: Present Status and by Michael Balls, James Bridges, Jacqueline Southee

By Michael Balls, James Bridges, Jacqueline Southee

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Additional resources for Animals and Alternatives in Toxicology: Present Status and Future Prospects

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The list begins with paracetamol, it continues with aspirin, and includes some common salts and a number of alcohols. I want to say that I fully agree with you that the basic toxicokinetics, including the biotransformation of compounds must be taken into consideration, and that was a major part of my presentation. When I showed the correlation between the pooled results, using a multivariate analysis predicting a one to one correlation, not a least mean squares or something like that, but a one to one using PLS analysis, the methods incolved included primary cultures of human hepatocytes, otherwise the fit would not have been as good.

5. US Environmental Protection Agency (1979). Proposed health effects test standards for Toxic Substances Control Act test rules and proposed good laboratory practice standards for health effects. Federal Register 44, 44054-44059, 44066-44067. 6. Anon. (1978). Council Directive 781631/EEC as to the classification, packaging and labelling of dangerous preparations (pesticides). Official Journal of the European Communities L206, 13--23. 7. US Environmental Protection Agency (1978). Proposed guidelines for registering pesticides in the US.

The current attitude of regulatory authorities to phototoxicity testing of chemicals and drugs should be established in the respective guidelines; b. Where animal testing is included in guidelines, suitable review by recognised experts should be conducted to establish the best method(s), with clear emphasis on the reduction of the number of animals used; c. Consideration should be given to the use of ethically conducted studies in human volunteers. e. freedom from effects. In this area, involving likely or intentional eye contamination, it seems highly unlikely that in vitro techniques could replace the living eye as a test model.

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