Laboratory Medicine

Alzheimer's disease : methods and protocols by N M Hooper; Humana Press

By N M Hooper; Humana Press

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Montoya, S. , Aston, C. , DeKosky, S. , Kamboh, M. , Lazo, J. , and Ferrell, R. E. (1998) Bleomycin hydroloase is associated with risk of sporadic Alzheimer’s disease. Nature Genet. 18, 211–212. 111. , Haines, J. , Scott, W. , et al. (1998) Analysis of the association between bleomycin hydrolase and Alzheimer ’s disease in Caucasians. Neurobiol. Aging 19, S68. 112. , Wilcox, M. , Laird, N. , Horvath, S. , Go, P. C. , et al. (1998) Alpha-2-macroglobulin is genetically asociated with Alzheimer’s disease.

George-Hyslop contribute, possibly by causing increased Αβ deposition, resulting in a similar clinical and neuropathological phenotype. Despite the considerable advances made in delineating genetic determinants of AD, the precise biochemical events leading to the disease phenotype remain to be fully elucidated. Following the identification of mutant genes, the ultimate goal is to characterize the normal and pathophysiological mechanisms involved through the generation of animal and cellular models.

81. Schellenberg, G. , Wijsman, E. , Moore, D. , Martin, G. , and Bird, T. D. (1992) Genetic association and linkage analysis of the Ap°CII locus and familial Alzheimer’s disease. Ann. Neurol. 31, 223–227. 82. Bullido, M. , Artiga, M. , Garcia, M. , et al. (1998). A polymorphism in the regulator region of Apolipoprotein E associated with risk for Alzheimer’s dementia. Nature Genet. 18, 69–71. 42 Brindle and St. George-Hyslop 83. , et al. (1998) Absence of association between Alzheimer disease and the –491 regulatory region polymorphism of APOE.

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