Therapy

Adenoviruses: Model and Vectors in Virus-Host Interactions: by G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr.

By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)

After 3 volumes on adenoviruses in 1995 the previous years have obvious fast development within the box of adenovirus examine. in addition, adenoviruses have attracted huge curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity bargains with the immune process, oncogenesis and gene treatment.

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Additional resources for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy

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E. Blair and M. E. Blair Zajdel Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, Biassoni R, Moretta L (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev ImmunoI19:197-223 O'Malley BW, Conneely OM (1992) Orphan receptors: In search of a unifying hypothesis for activation. Mol EndocrinoI92:1359-1361 Ozawa K, Hagiwara H, Tang X, Saka F, Kitabayashi I. Shiroki K, Israel A, Gachelin G, Yokoyama K (1993) Negative regulation of the gene for H-2Kb class I antigen by adenovirus 12 EIA is mediated by a CAA repeated element.

SK, may also confer resistance against TNFa-mediated cytolysis and down-regulates the epidermal growth factor receptor (EGFR) from the cell surface (Mahr and Gooding 1999; Wold et al. 1999; Burgert and Blusch 2000). Moreover, the same protein complex (also called RID, for receptor internalization and degradation) dramatically reduces the expression of the apoptosis receptor Fas on the cell surface of infected cells by inducing its internalization and degradation in lysosomes (Shisler et al. 1997; Elsing and Burgert 1998; Tollefson et al.

Cell 28:387-394 Sawada Y, F6hring B, Shenk TE, Raska K (1985) Tumorigenicity of adenovirus-transformed cells: region E1A of adenovirus 12 confers resistance to natural killer cells. Virology 147:413-421 Screpanti V, Wallin RPA, Ljunggren H-G, Grandien A (2001) A central role for death receptor-mediated apoptosis in the rejection of tumours by NK cells. I Immunol 167:2068-2073 Seliger B, Wollsheid U, Momburg F, Blankenstein T, Huber C (2000) Coordinate downregulation of multiple MHC class I antigen processing genes in chemical-induced murine tumor cell lines of distinct origin.

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